Challenges in Toxicology and Risk Assessment

Dr. Gerhard Hager and Paolo Rossato

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PROGRAMM_ASTOX2019

University of Vienna
Faculty of Physics – Boltzmanngasse 5, 1st Floor – Lise Meitner Lecture Hall – A-1090 Vienna, Austria

Programme

Session 1: Chemical Mixtures

  • Keynote Lecture – The EFSA Guidance on risk assessment for human, managed animals, and ecosystems of combined exposure to multiple chemicals
  • ChemCock: Introduction to the Austrian project on chemical mixtures
  • ChemCock: The modified Reference Point Index (mRPI) – an Approach to Assess Risks of Food Contaminant Mixtures
  • ChemCock: Some examples for cumulative risk assessment of chemical mixtures of contaminants
  • Keynote Lecture – The EuroMix test strategy to generate data for future mixture risk assessment

Session 2: Biotoxins

  • Use of Next Generation Sequencing to identify the molecular basis of disorders
  • Cell Membrane: structure and biophysical properties determining response to toxicants
  • Toxicological characterisation of mycotoxins and their degradation products
  • Insights into the toxicity of prymnesins, toxic metabolites of the microalgae Prymnesium parvum
  • Immunomodulatory effects of the Fusarium secondary metabolite butenolide in human colon epithelial cells
  • Combinatory Effects of Deoxynivalenol and the Emetic Bacterial Toxin Cereulide on Cell Viability of Caco-2 Monolayers

Session 3: Hot Topics

  • Biological connectivity and the exposome: a paradigm shift towards precision prevention
  • Global metabolomics as a key technology for deciphering toxin exposure and effect
  • Fate of the mycotoxin deoxynivalenol during baking
  • Review of maximum residue levels of tau-fluvalinate according to Regulation (EC) No 396/2005
  • Acid protective formulation of omeprazole using β-lactoglobulin and mesoporous silica nanoparticles: insightful in vitro release, cytotoxicity and mitochondrial morphology effects
  • Mercury-containing Creams – Not only a Problem for the User!

Session 4: Medicinal Products

  • Facing challenges transitioning from basic research to early non-clinical development
  • ADME in Safety Testing of Pharmaceuticals, something to talk about?
    Dr. Gerhard Hager
  • Marketing surveillance of medicinal products (legal & illegal market)
  • The Environmental Risk Assessment of Human Medicinal Products
  • Impact of coccidiostats on the environment, ecotoxicological aspects

Session 5: Perfluorinated Alkylated Substances

  • Tackling Perfluorinated Alkylated Substances: A Brief Update on the Toxicity of this Compound Class and on Regulatory Activities
  • Occurrence of per- and polyfluoroalkyl substances (PFAS), chemicals with known endocrine disrupting activity, in drinking water, groundwater and surface water, Austria 2017/2018
  • Human Biomonitoring of perfluoroalkyl substances within HBM4EU and in Austria
  • Exposure to perfluoralkyl substances (PFAS) of pregnant women and its potential impact on fetal growth
  • Effects of PFAS on placental vascularization

 

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